5-LOX Inhibitor with AprèsFlex

Excess levels of the enzyme 5-lipoxygenase or 5-LOX sets in motion inflammatory responses that has been linked to common degenerative effects in aging individuals (1-5). Normal aging results in higher-than-desired levels of 5-LOX.

The typical American diet adds to the danger. Foods rich in omega-6 fatty acids like red meat, poultry, eggs and dairy products, along with high-glycemic carbohydrates, trigger overproduction of arachidonic acid. In response to high levels of arachidonic acid, the body produces the 5-LOX enzyme.

5-LOX breaks down arachidonic acid to pro-inflammatory compounds like leukotriene B4 (6), a molecule that attacks joints, arterial walls, and other tissues. 5-LOX itself facilitates undesirable cell division changes.

The good news is that extract of the Indian plant Boswellia serrata has been shown to neutralize 5-LOX. Used for centuries to help with inflammatory issues, boswellia acts a natural 5-LOX inhibitor, intervening at the cellular level to block its unwanted effects. Confirmatory data reveal that a compound contained in boswellia called AKBA (3-O-acetyl-11-keto-ß-boswellic acid) (7,8) is the key to its beneficial action. The problem is that boswellia is not readily absorbed into the blood (9).

For this reason, a patent-pending, standardized form of boswellia called AprèsFlex™ is being introduced that absorbs into the blood 52% more than previously available boswellia extracts (9). Each 100 mg vegetarian capsule of 5-LOX Inhibitor with AprèsFlex™ is standardized to provide 20% of active AKBA from boswellia. Most people need only one capsule a day.
 
References
1. Neurobiol Aging. 2007 Sep;28(9):1457-62.
2. Cardiovasc Psychiatry Neurol. 2009;2009:174657.
3. Free Radic Biol Med. 2009 Jul 1;47(1):62-71.
4. Rejuvenation Res. 2009 Feb;12(1):15-24.
5. Available at: http://www.cdc.gov/nchs/fastats/lcod.htm. Accessed July 29, 2011.
6. Curr Opin Investig Drugs. 2009 Nov;10(11):1163-72.
7. Wien Med Wochenschr. 2002;152(15-16):373-8.
8. J Ethnopharmacol. 2006 Sep 19;107(2):249-53.
9. Mol Cell Biochem. 2011 Aug;354(1-2):189-97. 

Supplement Facts

Serving Size 1 vegetarian capsule
Servings Per Container 60

Amount Per Serving

AprèsFlex (Boswellia serrata) extract (gum resin) [std. to 20% 3-O-acetyl-11- keto-ß-boswellic acid (AKBA) (20 mg)] 100 mg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.

AprèsFlex is a trademark of Laila Nutraceuticals exclusively licensed to P.L. Thomas-Laila Nutra LLC. International patents pending.

Dosage and Use

To inhibit the 5-lipoxygenase enzyme, take one capsule daily with or without food, or as recommended by a healthcare practitioner.

Caution:

Keep out of reach of children.

Do not exceed recommended dose.

Do not purchase if outer seal is broken or damaged.

If you have a bad reaction to product discontinue use immediately.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.