Mitochondrial Energy Optimizer with BioPQQ
Aging is characterized by inflammation, glycation and mitochondrial decay. Mitochondria are the energy-producing powerhouses of the cells and are found in highest concentrations in metabolically active organs such as the brain, heart, and skeletal muscles. Currently, the only known strategies to generate new mitochondria are long-term, strenuous aerobic exercise or caloric restriction, which are difficult or impractical for most people to implement. Now, Life Extension members have an alternative to counteract the age-related decline in mitochondria with the new Mitochondrial Energy Optimizer with Bio-PQQ™.
Mitochondrial Energy Optimizer with Bio-PQQ™ is the most complete mitochondrial support formula on the market. It contains a broad spectrum of ingredients to counteract the primary factors of aging while enhancing the ability of mitochondria to produce energy (ATP). The newest addition, an essential micronutrient known as PQQ has actually been shown to stimulate the production of new mitochondria (102)!
This cutting-edge formula provides nutrients to counteract mitochondrial decay (one of the primary factors of aging), nutrients to boost the mitochondrial energy-producing capacity, and now, PQQ. Research has confirmed that PQQ’s cell-signaling effects translate to benefits for the cardiovascular, nervous, reproductive and immune systems.
Mitochondrial Energy Optimizer is designed to counteract age-related structural and functional changes by providing the following unique ingredients:
* Carnosine
As humans age, their proteins become irreversibly damaged by lethal glycation reactions. Glycation is the cross-linking of proteins and sugar to form non-functioning structures in the body, which can lead to alterations of normal cell function. Carnosine is not only the premier anti-glycating agent, but it also protects neurons against reactive and cytotoxic protein carbonyl species associated with normal aging (11-15).
* Luteolin
Unremitting systemic inflammation is involved with virtually every undesirable consequence of aging. Culprits behind chronic inflammatory reactions are pro-inflammatory cytokines, such as interleukin-1 and tumor necrosis factor alpha. Luteolin is a super-potent plant extract that has been shown to suppress these dangerous inflammatory cytokines (16-22).
* Benfotiamine
Benfotiamine blocks multiple destructive biochemical pathways, including AGEs’ formation pathway, which is induced by higher than desirable blood glucose levels. Human mortality studies indicate that ideal fasting glucose levels are between 74–85 mg/dL. Yet many aging people have fasting glucose above 90 mg/dL, which is less than optimal (23-25). Benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. In addition, benfotiamine exhibits direct antioxidative capacity and prevents induction of DNA damage (26).
* Pyridoxal 5’-phosphate
Aging results in the formation of toxic advanced glycation end products throughout the body. Pyridoxal 5’-phosphate is the active form of vitamin B6 that has been shown to protect against both lipid and protein glycation reactions (27-29).
* R-lipoic acid
Destructive free radical activity in the mitochondria plays a major role in the loss of cellular vitality. The microencapsulated Bio-Enhanced® R-lipoic acid facilitates youthful mitochondrial energy output while guarding against free radicals. Two forms of lipoic acid are sold on the supplement market, but R-lipoic acid is far more potent (30-35).
* Acetyl-L-carnitine arginate
The amino acid L-carnitine is required to transport fats into the mitochondria to be burned for cellular energy. ArginoCarn® Acetyl-L-carnitine arginate is a patented form of carnitine that has been shown in cell cultures to stimulate the growth of neuritis (36-38).
* BioPQQ™
The newest addition to Mitochondrial Energy Optimizer. While all the other nutrients in this formula support the structure or function of mitochondria, PQQ has been shown to stimulate the production of new mitochondria. In humans, PQQ has been shown to support healthy levels of CRP and plasma antioxidant potential, as well as to promote memory, attention, and cognition in maturing individuals. In animals, it has demonstrated the ability to support cardiovascular, immune, neurological, and reproductive health (102).
References
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12. Protein Pept Lett. 2008;15(4):385-91.
13. J Alzheimers Dis. 2007 May;11(2):229-40.
14. Ann N Y Acad Sci. 2006 May;1067:369-74.
15. Sci Aging Knowledge Environ. 2005 May 4;2005(18):pe12.
16. Life Sci. 2007 Nov 30;81(23-24):1602-14.
17. J Nutr. 2006 Jun;136(6):1517-21.
18. J Neuroinflammation. 2008 Sep 25;5:41.
19. Immunology. 2005 Jul;115(3):375-87.
20. Am J Respir Crit Care Med. 2002 Mar 15;165(6):818-23.
21. Eur J Pharmacol. 2006 Jul 10;541(1-2):95-105.
22. Neurosci Lett. 2008 Dec 26;448(2):175-9.
23. Nat Med. 2003 Mar;9(3):294-9.
24. Acta Diabetol. 2001;38(3):135-8.
25. Diabetes. 2006 Aug;55(8):2231-7.
26. Diabetes Metab Res Rev. 2008 Jul-Aug;24(5):371-7
27. J Lipid Res. 2006 May; 47(5): 964-74
28. J Am Soc Nephrol. 2005 Jan;16(1):144-50.
29. Life Sci. 1988;43(21):1725-31.
30. Biochem Biophys Res Commun. 1996 Apr 16;221(2):422-9.
31. FASEB J. 1999 Feb;13(2):411-8.
32. Antioxid Redox Signal. 2000 Fall;2(3):473-83.
33. Biochem Mol Biol Int. 1995 Oct;37(2):361-70.
34. Arch Biochem Biophys. 2004 Mar 1;423(1):126-35.
35. Redox Rep. 2005;10(1):52-60.
36. Altern Med Rev. 2005 Dec;10(4):268-93.
37. Neurosci Lett. 1994 Jan 3;165(1-2):33-6.
38. Neurochem Res. 1995 Jan;20(1):1-9.
102. Altern Med Rev. 2009 Sep;14(3):268-77.
Supplement Facts
Serving Size 4 capsules
Servings Per Container 30
Amount Per Serving
Vitamin B6 (as pyridoxal 5’-phosphate) 100 mg
Calcium (as calcium carbonate) 175 mg
Sodium 25 mg
Carnosine 1000 mg
ArginoCarn® Acetyl-L-carnitine arginate dihydrochloride 675 mg
Benfotiamine 150 mg
R-Lipoic Acid (as microencapsulated Bio-Enhanced® stabilized Na-RALA sodium R-lipoate) 150 mg
BioPQQ™ Pyrroloquinoline quinone disodium salt 10 mg
Luteolin (high purity luteolin as Pureolin™) 8 mg
Other ingredients: gelatin, vegetable stearate, silica.
Contains soybeans.
Bio-Enhanced® is a registered trademark of Geronova Research, Inc.
Pureolin™ is a trademark of Pharma Science Nutrients, Inc., and is used here under license. All rights reserved worldwide.
BioPQQ™ is a trademark of MGC (Japan).
ArginoCarn® is a registered trademark of Sigma-tau HealthSciences, Inc. and is protected by US patents 6,365,622, US 6,703,042 and EP1202956.
Dosage and Use
Take two capsules twice daily, preferably early in the day or all at once upon wakening, or as recommended by a healthcare practitioner.
This product can be taken with or without food.
Warnings:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
