Optimized Folate (L-Methylfolate)

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Those who take ordinary folic acid supplements, however, may not be experiencing its full spectrum of effects. This is because folic acid is itself not biologically active, but its biological importance is due to its active form called  5-methyltetrahydrofolate (5-MTHF) after its conversion to dihydrofolic acid in the liver (9). Research shows that in a large proportion of the population, genetic dihydrofolate reductase enzyme deficiencies limited the conversion of folate to 5-MTHF, leaving many vulnerable to low blood 5-MTHF levels (and higher than desired homocysteine).

A more useful approach is to take the bioactive folate 5-MTHF directly, which has been declassified as a drug and is now available as a dietary supplement. 5-MTHF has been shown to dramatically raise red blood cell folate levels (10) compared with folic acid supplementation. 5-MTHF is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency (11) since 5-MTHF requires no conversion to be biologically active.

People with elevated homocysteine levels have a greater risk of cognitive decline (13). Unlike folic acid, 5-MTHF is able to cross the blood-brain barrier, which is especially important for people with cognitive difficulties to enhance the synthesis of acetylcholine in the brain — the neurotransmitter associated with memory.

Studies also show that the effectiveness of 5-MTHF can be further enhanced by co-supplementing with methylcobalamin (the active form of vitamin B12) (14),  vitamin B6, and riboflavin (15).

Optimized Folate now provides Quatrefolic 5-methyltetrahydrofolate complexed with glucosamine for longer stability, higher water solubility and improved bioavalability compared to other forms of 5-MTHF.
 
References
9. Proc Natl Acad Sci U S A. 2009; 106(36): 15424–15429.
10. Am J Clin Nutr. 2006 Jul;84(1):156-61
11. Br J Pharmacol. 2004 Mar;141(5):825-30.
13. N Engl J Med. 2002 Feb 14;346(7):476-83.
14. Nephrol Dial Transplant. May 2002;17(5):916-22.
15. Clin Chem.2000 Aug;46(8 Pt 1):1065-71.

Supplement Facts

Serving Size 1 vegetarian capsule
Servings Per Container 100
 
Amount Per Serving

Folate (as (6S)-5-Methyltetrahydrofolic acid, glucosamine salt)  1000 mcg

Other ingredients: microcrystalline cellulose, vegetable cellulose (capsule), silica, vegetable stearate.
 
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
 
Dosage and Use
 
Take one capsule daily with food, or as recommended by a healthcare practitioner.

Quatrefolic is a registered trademark of Gnosis, S.p.A.
 
Caution:

Keep out of reach of children.

Do not exceed recommended dose.

Do not purchase if outer seal is broken or damaged.

If you have a bad reaction to product discontinue use immediately.

When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.