Arginine & Ornithine
L-arginine is an essential amino acid. Arginine, a semi-essential amino acid, is involved in numerous areas of human biochemistry, including ammonia detoxification, hormone secretion, and immune modulation. Arginine is also well known as a precursor to nitric oxide (NO), a key component of endothelial-derived relaxing factor, an endogenous messenger molecule involved in a variety of endothelium-dependent physiological effects in the cardiovascular system.
L-ornithine is sometimes used as an alternative since arginine is metabolized into this amino acid, among other compounds. L-arginine is required for the body to synthesize nitric oxide, which enables the arterial system to retain its youthful elasticity. Nitric oxide also helps to produce endothelial relaxation factor, which is needed by the arterial system to expand and contract with each heartbeat (29-43).
L-arginine may also help stimulate the immune system (44). Surgical or traumatic injury greatly increases the body's need for L-arginine, a key building block to maintaining healthy tissue and bone. L-ornithine may also be used for this purpose (45-56).
References
29. Hypertension. 1999 Jul;34(1):44-50.
30. J Thorac Cardiovasc Surg. 1995 Aug;110(2):302-14.
31. Circulation. 1994 Sep;90(3):1357-62.
32. Surgery. 1994 Sep;116(3):557-68.
33. Chest. 1993 Apr;103(4):1241-5.
34. Stroke. 1993 Mar;24(3):392-9.
35. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1251-6.
36. Biomed Pharmacother. 2002 Nov;56(9):439-45.
37. Atherosclerosis. 1998 Nov;141(1):31-43.
38. Tidsskr Nor Laegeforen. 1992 Aug 20;112(19):2531-5.
39. Nature. 1988 Jun 16;333(6174):664-6.
40. J Nutr. 2000 Nov;130(11):2626-9.
41. Clin Cardiol. 2000 Mar;23(3):205-10.
42. Hypertens Pregnancy. 2007;26(1):121-30.,
43. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E906-12.
44. Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):80-7.
45. Pediatrics. 1981 Aug;68(2):260-4.
46. Altern Med Rev. 2003 Nov;8(4):359-77.
47. Surg Clin North Am. 2003 Jun;83(3):571-96.
48. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):223-8.
49. Isr Med Assoc J. 2002 Sep;4(9):713-6
50. Ann Surg. 2002 Sep;236(3):369-74; discussion 374-5.
51. JPEN J Parenter Enteral Nutr. 2000 Sep-Oct;24(5):280-7.
52. Eur J Clin Nutr. 2000 Aug;54(8):615-7.
53. Curr Opin Clin Nutr Metab Care. 2000 Jan;3(1):59-66.
54. J Nutr. 1998 May;128(5):797-803. Review.
55. J Parenter Enteral Nutr. 1995 May-Jun;19(3):227-30. Erratum in: J Parenter Enteral Nutr 1995 Jul-Aug;19(4):329.
56. Ann Fr Anesth Reanim. 1995;14 Suppl 2:102-6.
Supplement Facts
Serving Size 2 capsules
Servings Per Container 50
Amount Per Serving
L-Arginine (Free-Form) 1 g
L-Ornithine (from L-Ornithine HCl) 500 mg
Other ingredients: gelatin (capsule) and magnesium stearate (vegetable source).
Contains no sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.
Dosage and Use
As a dietary supplement, take 2 capsules 2 to 3 times daily, preferably with juice or water on an empty stomach, before exercise or at bedtime.
Caution
This supplement should be avoided by persons with glaucoma or herpes simplex unless otherwise prescribed by a physician. Do not use if you have had a myocardial infarction or have established coronary artery disease.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
L-ornithine is sometimes used as an alternative since arginine is metabolized into this amino acid, among other compounds. L-arginine is required for the body to synthesize nitric oxide, which enables the arterial system to retain its youthful elasticity. Nitric oxide also helps to produce endothelial relaxation factor, which is needed by the arterial system to expand and contract with each heartbeat (29-43).
L-arginine may also help stimulate the immune system (44). Surgical or traumatic injury greatly increases the body's need for L-arginine, a key building block to maintaining healthy tissue and bone. L-ornithine may also be used for this purpose (45-56).
References
29. Hypertension. 1999 Jul;34(1):44-50.
30. J Thorac Cardiovasc Surg. 1995 Aug;110(2):302-14.
31. Circulation. 1994 Sep;90(3):1357-62.
32. Surgery. 1994 Sep;116(3):557-68.
33. Chest. 1993 Apr;103(4):1241-5.
34. Stroke. 1993 Mar;24(3):392-9.
35. Biochem Biophys Res Commun. 1988 Jun 30;153(3):1251-6.
36. Biomed Pharmacother. 2002 Nov;56(9):439-45.
37. Atherosclerosis. 1998 Nov;141(1):31-43.
38. Tidsskr Nor Laegeforen. 1992 Aug 20;112(19):2531-5.
39. Nature. 1988 Jun 16;333(6174):664-6.
40. J Nutr. 2000 Nov;130(11):2626-9.
41. Clin Cardiol. 2000 Mar;23(3):205-10.
42. Hypertens Pregnancy. 2007;26(1):121-30.,
43. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E906-12.
44. Curr Opin Clin Nutr Metab Care. 2007 Jan;10(1):80-7.
45. Pediatrics. 1981 Aug;68(2):260-4.
46. Altern Med Rev. 2003 Nov;8(4):359-77.
47. Surg Clin North Am. 2003 Jun;83(3):571-96.
48. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):223-8.
49. Isr Med Assoc J. 2002 Sep;4(9):713-6
50. Ann Surg. 2002 Sep;236(3):369-74; discussion 374-5.
51. JPEN J Parenter Enteral Nutr. 2000 Sep-Oct;24(5):280-7.
52. Eur J Clin Nutr. 2000 Aug;54(8):615-7.
53. Curr Opin Clin Nutr Metab Care. 2000 Jan;3(1):59-66.
54. J Nutr. 1998 May;128(5):797-803. Review.
55. J Parenter Enteral Nutr. 1995 May-Jun;19(3):227-30. Erratum in: J Parenter Enteral Nutr 1995 Jul-Aug;19(4):329.
56. Ann Fr Anesth Reanim. 1995;14 Suppl 2:102-6.
Supplement Facts
Serving Size 2 capsules
Servings Per Container 50
Amount Per Serving
L-Arginine (Free-Form) 1 g
L-Ornithine (from L-Ornithine HCl) 500 mg
Other ingredients: gelatin (capsule) and magnesium stearate (vegetable source).
Contains no sugar, salt, starch, yeast, wheat, gluten, corn, soy, milk, egg, shellfish or preservatives.
Dosage and Use
As a dietary supplement, take 2 capsules 2 to 3 times daily, preferably with juice or water on an empty stomach, before exercise or at bedtime.
Caution
This supplement should be avoided by persons with glaucoma or herpes simplex unless otherwise prescribed by a physician. Do not use if you have had a myocardial infarction or have established coronary artery disease.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
