Mega Benfotiamine
Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), supports healthy blood sugar metabolism and helps protect the body's tissues against advanced glycation end products and oxidative stress (13). For example, the enzyme transketolase is critical to blood sugar metabolism. Like many enzymes, transketolase requires a co-factor. In this case, it needs assistance from thiamine. Unfortunately, thiamine is water-soluble, which makes it less available to the interior of the cell. Benfotiamine is fat-soluble and can easily penetrate into the inside of cells. It is also more bioavailable than the water-soluble thiamine.
In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage (14). Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions (13).
Overall, benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. It can also reduce formation of advanced glycation end products to prevent glucose toxicity and correct endothelial cell defects caused by high concentrations of blood glucose, especially inside endothelial, retinal, kidney and nerve cells. Benfotiamine also helps maintain healthy endothelial function (15-21). Benfotiamine with thiamine is a low-cost dietary supplement that can help maintain already-normal blood sugar levels and support the health of the nerves, kidneys, eyes, blood vessels, and heart.
References
13. Nature Med. 2003 Mar;9(3):294-9.
14. Postepy Hig Med Dosw (Online). 2008 Sep 5;62:451-62.
15. Diabetes Care. 2006 Sep;29(9):2064-71.
16. Ann N Y Acad Sci. 2005 Jun;1043:777-83.
17. Diabetes Metab Res Rev. 2004 Jul-Aug;20(4):330-6.
18. Diabetes. 2003 Aug;52(8):2110-20.
19. Acta Diabetol. 2001;38(3):135-8.
20. Diabetes. 2006 Aug;55(8):2231-7.
21. Ann N Y Acad Sci. 2005 Jun;1043:784-92.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 120
Amount Per Serving
Vitamin B1 (as thiamin HCl) 10 mg
Benfotiamine 250 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, dicalcium phosphate, rice flour, vegetable stearate, silica.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one to four capsule(s) daily with or without food, or as recommended by a healthcare practitioner.
Caution:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways leading to blood vessel damage (14). Benfotiamine also blocks the activation of the transcription factor known as nuclear factor-kappa B (NF-kB), which is implicated in numerous inflammatory conditions (13).
Overall, benfotiamine can activate glucose metabolism and promote already healthy blood glucose levels. It can also reduce formation of advanced glycation end products to prevent glucose toxicity and correct endothelial cell defects caused by high concentrations of blood glucose, especially inside endothelial, retinal, kidney and nerve cells. Benfotiamine also helps maintain healthy endothelial function (15-21). Benfotiamine with thiamine is a low-cost dietary supplement that can help maintain already-normal blood sugar levels and support the health of the nerves, kidneys, eyes, blood vessels, and heart.
References
13. Nature Med. 2003 Mar;9(3):294-9.
14. Postepy Hig Med Dosw (Online). 2008 Sep 5;62:451-62.
15. Diabetes Care. 2006 Sep;29(9):2064-71.
16. Ann N Y Acad Sci. 2005 Jun;1043:777-83.
17. Diabetes Metab Res Rev. 2004 Jul-Aug;20(4):330-6.
18. Diabetes. 2003 Aug;52(8):2110-20.
19. Acta Diabetol. 2001;38(3):135-8.
20. Diabetes. 2006 Aug;55(8):2231-7.
21. Ann N Y Acad Sci. 2005 Jun;1043:784-92.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 120
Amount Per Serving
Vitamin B1 (as thiamin HCl) 10 mg
Benfotiamine 250 mg
Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, dicalcium phosphate, rice flour, vegetable stearate, silica.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one to four capsule(s) daily with or without food, or as recommended by a healthcare practitioner.
Caution:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
250 mg, 120 vegetarian capsules
Article no.: 925| # | Price | Discount Card |
|---|---|---|
| 1 | € 28,55 | € 25,70 |
| 3 | € 27,12 | € 24,41 |
