Micronized Creatine Powder
Creatine is a non-protein amino acid derivative found in human tissue that is synthesized from the amino acids L-arginine, glycine, and L-methionine. Synthesized creatine is metabolized into phosphocreatine, an important storage form used by the brain, heart, and skeletal muscles (40). In normal healthy individuals, muscle creatine is replenished at a rate of approximately two grams a day (41). Oral ingestion of creatine has been shown to suppress the body's natural production, an effect that has been shown to be reversed upon ceasing supplementation (41).
Creatine exerts various effects upon entering the muscle. It is these effects that elicit improvements in exercise performance and may be responsible for the improvements of muscle function and energy metabolism seen under certain conditions. Several mechanisms have been proposed to explain the increased exercise performance seen after creatine intake (42).
1. Optimizing energy metabolism by maintaining higher levels of the body's energy compound adenosine triphosphate or ATP (43-45)
2. Increasing myofibrillar mRNA content and protein synthesis, and reducing amino acid oxidation and protein breakdown (42,46,47)
3. Increasing satellite cell and myonuclei number and activity in human skeletal muscle (48)
4. Preventing tissue damage by stabilizing cellular membranes and maintaining reserves of ATP (42)
Creatine monohydrate has become popular with athletes, but it may also be beneficial for people who are nutritionally deficient, have conditions associated with low cellular energy, muscle weakness, and those concerned with the muscular integrity of the heart (49-57).
References
40. Can J Appl Physiol. 1999 Dec;24(6):503-14.
41. Adv. Enzymol Relat Areas Mol Biol. 1979;50:177-242.
42. Pharmacol Rev. 2001 Jun;53(2):161-76.
43. Nutr Biochem. 1997; 8(11): 610-8.
44. Annu Rev Biochem. 1985;54:831-62.
45. Am J Physiol. 1984 May;246(5 Pt 1):C365-C377.
46. Med Sci Sports Exerc. 2001 Oct;33(10):1674-81.
47. J Appl Physiol 2001;91: 1041-1047.
48. J Physiol 2006;573: 525-534
49. Arthritis Rheum. 1998 Mar;41(3):406-13.
50. Neurology. 2000 May 9;54(9):1848-50.
51. Neurology. 1999 Mar 10;52(4):854-7.
52. Brain Res. 2000; 860(1-2): 195-8.
53. Amino Acids Abstract. 2002;23(1-3):221-29.
54. J Neurosci. 2000; 20(12):4389-97.
55. Nat Med. 1999; 5(3):347-50.
56. Cardiovasc Res. 1995 Sep; 30(3): 413-8.
57. Eur Heart J. 1998 Apr;19(4):617-22.
Supplement Facts
Serving Size 1/4 teaspoon (approximately 1250 mg)
Servings Per Container approximately 400
Amount Per Serving
CREAPURE® creatine monohydrate (micronized) 1250 mg
Other ingredients: none.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
CREAPURE® is a registered trademark of AlzChem Trostberg GmbH, Germany, US Reg. No 2715915.
Dosage and Use
Take 1/4 teaspoon once daily.
Take with meals or immediately following exercise.
Mix with juice, water, or protein drink, or as recommended by a healthcare practitioner.
Caution
People with impaired kidney function should avoid creatine supplements.
Warnings
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Creatine exerts various effects upon entering the muscle. It is these effects that elicit improvements in exercise performance and may be responsible for the improvements of muscle function and energy metabolism seen under certain conditions. Several mechanisms have been proposed to explain the increased exercise performance seen after creatine intake (42).
1. Optimizing energy metabolism by maintaining higher levels of the body's energy compound adenosine triphosphate or ATP (43-45)
2. Increasing myofibrillar mRNA content and protein synthesis, and reducing amino acid oxidation and protein breakdown (42,46,47)
3. Increasing satellite cell and myonuclei number and activity in human skeletal muscle (48)
4. Preventing tissue damage by stabilizing cellular membranes and maintaining reserves of ATP (42)
Creatine monohydrate has become popular with athletes, but it may also be beneficial for people who are nutritionally deficient, have conditions associated with low cellular energy, muscle weakness, and those concerned with the muscular integrity of the heart (49-57).
References
40. Can J Appl Physiol. 1999 Dec;24(6):503-14.
41. Adv. Enzymol Relat Areas Mol Biol. 1979;50:177-242.
42. Pharmacol Rev. 2001 Jun;53(2):161-76.
43. Nutr Biochem. 1997; 8(11): 610-8.
44. Annu Rev Biochem. 1985;54:831-62.
45. Am J Physiol. 1984 May;246(5 Pt 1):C365-C377.
46. Med Sci Sports Exerc. 2001 Oct;33(10):1674-81.
47. J Appl Physiol 2001;91: 1041-1047.
48. J Physiol 2006;573: 525-534
49. Arthritis Rheum. 1998 Mar;41(3):406-13.
50. Neurology. 2000 May 9;54(9):1848-50.
51. Neurology. 1999 Mar 10;52(4):854-7.
52. Brain Res. 2000; 860(1-2): 195-8.
53. Amino Acids Abstract. 2002;23(1-3):221-29.
54. J Neurosci. 2000; 20(12):4389-97.
55. Nat Med. 1999; 5(3):347-50.
56. Cardiovasc Res. 1995 Sep; 30(3): 413-8.
57. Eur Heart J. 1998 Apr;19(4):617-22.
Supplement Facts
Serving Size 1/4 teaspoon (approximately 1250 mg)
Servings Per Container approximately 400
Amount Per Serving
CREAPURE® creatine monohydrate (micronized) 1250 mg
Other ingredients: none.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
CREAPURE® is a registered trademark of AlzChem Trostberg GmbH, Germany, US Reg. No 2715915.
Dosage and Use
Take 1/4 teaspoon once daily.
Take with meals or immediately following exercise.
Mix with juice, water, or protein drink, or as recommended by a healthcare practitioner.
Caution
People with impaired kidney function should avoid creatine supplements.
Warnings
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
