SAMe (S-adenosyl-methionine)
SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:
* Methylation (contributing methyl groups to activate certain molecules) (16,17)
* The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) (18-20)
* Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals) (21-23)
SAMe occurs naturally in the body; it is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways (24). SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.
SAMe levels may become depleted from sickness and age. Supplementation of the co-factors - folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe - appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine (16,17,19,22-23,25).
In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Their findings show the efficacy of SAMe in helping maintain stable mood and joint function, without any side effects (26). Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older (18,27-32). In addition, SAMe has multi-modal mechanisms of action that are used throughout the body, and especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage.
References
16. Pharmacol Biochem Behav. 2001 Sep;70(1):105-14.
17. Biochim Biophys Acta. 1983 Nov 23;735(3):367-79.
18. Neuroreport. 2001 Dec 21;12(18):3939-42.
19. Drugs. 1994 Aug;48(2):137-52.
20. Acta Neurol Scand Suppl. 1994;154:19-26.
21. Scand J Gastroenterol. 1989 May;24(4):407-15.
22. Dig Dis Sci. 1998 Oct;43(10):2211-22.
23. Minerva Gastroenterol Dietol. 1992 Jul-Sep;38(3):145-51.
24. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S
25. Mech Ageing Dev. 1984 Aug;26(2-3):149-64.
26. Evidence Report/Technology Assessment: Number 64 S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease http://www.ahrq.gov/clinic/epcsums/samesum.htm
27. Br J Pharmacol. 1999 Jun;127(3):645-54.
28. Zhonghua Wai Ke Za Zhi. 2002 Jun;40(6):407-10.
29. Kaohsiung J Med Sci. 2001 Sep;17(9):455-60.
30. Am J Clin Nutr. 2002 Nov;76(5):1151S-1157S.
31. Br J Rheumatol. 1997 Jan;36(1):27-31.
32. Rev Clin Esp. 1990 Jun;187(2):74-8.
Supplement Facts
Serving Size 1 tablet
Servings Per Container 20
Amount Per Serving
S-Adenosyl-Methionine 400 mg
Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors or preservatives.
Dosage and Use
Take one (1) tablet two to three times daily in divided doses morning, midday and late afternoon, or as recommended by a healthcare practitioner.
Take with co-factors vitamins B12, B6 and folic acid.
Taking this product with food may avoid gastro-intestinal disturbance.
Caution
SAMe should not be taken by those diagnosed with bipolar disorder.
Warnings
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
* Methylation (contributing methyl groups to activate certain molecules) (16,17)
* The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc.) (18-20)
* Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals) (21-23)
SAMe occurs naturally in the body; it is concentrated in the liver and brain and is a major methyl donor in the synthesis of hormones, nucleic acids, proteins, and phospholipids, catecholamines, and other neurotransmitters, such as dopamine and serotonin. SAMe is required for the synthesis of norepinephrine, dopamine, and serotonin, and also plays a role in other intracellular metabolic pathways (24). SAMe facilitates glutathione usage and maintains acetylcholine levels, which help enhance or maintain cognitive function and attenuate or prevent aggression of aging and neurodegeneration.
SAMe levels may become depleted from sickness and age. Supplementation of the co-factors - folate, trimethylglycine (TMG or betaine), vitamins B6 and B12, together with SAMe - appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid, and is used in the brain to make the neurotransmitter acetylcholine (16,17,19,22-23,25).
In 2002, an agency of the U.S. Department of Health and Human Services conducted a meticulous evaluation of SAMe. Their findings show the efficacy of SAMe in helping maintain stable mood and joint function, without any side effects (26). Since aging people often suffer joint discomfort and immobilization, SAMe addresses multiple problems people face as they grow older (18,27-32). In addition, SAMe has multi-modal mechanisms of action that are used throughout the body, and especially in the liver, which help maintain liver health. SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage.
References
16. Pharmacol Biochem Behav. 2001 Sep;70(1):105-14.
17. Biochim Biophys Acta. 1983 Nov 23;735(3):367-79.
18. Neuroreport. 2001 Dec 21;12(18):3939-42.
19. Drugs. 1994 Aug;48(2):137-52.
20. Acta Neurol Scand Suppl. 1994;154:19-26.
21. Scand J Gastroenterol. 1989 May;24(4):407-15.
22. Dig Dis Sci. 1998 Oct;43(10):2211-22.
23. Minerva Gastroenterol Dietol. 1992 Jul-Sep;38(3):145-51.
24. Am J Clin Nutr. 2002 Nov;76(5):1158S-61S
25. Mech Ageing Dev. 1984 Aug;26(2-3):149-64.
26. Evidence Report/Technology Assessment: Number 64 S-Adenosyl-L-Methionine for Treatment of Depression, Osteoarthritis, and Liver Disease http://www.ahrq.gov/clinic/epcsums/samesum.htm
27. Br J Pharmacol. 1999 Jun;127(3):645-54.
28. Zhonghua Wai Ke Za Zhi. 2002 Jun;40(6):407-10.
29. Kaohsiung J Med Sci. 2001 Sep;17(9):455-60.
30. Am J Clin Nutr. 2002 Nov;76(5):1151S-1157S.
31. Br J Rheumatol. 1997 Jan;36(1):27-31.
32. Rev Clin Esp. 1990 Jun;187(2):74-8.
Supplement Facts
Serving Size 1 tablet
Servings Per Container 20
Amount Per Serving
S-Adenosyl-Methionine 400 mg
Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, silica, stearic acid, glyceryl triacetate, sodium starch glycolate, croscarmellose sodium, titanium dioxide, yellow ochre.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors or preservatives.
Dosage and Use
Take one (1) tablet two to three times daily in divided doses morning, midday and late afternoon, or as recommended by a healthcare practitioner.
Take with co-factors vitamins B12, B6 and folic acid.
Taking this product with food may avoid gastro-intestinal disturbance.
Caution
SAMe should not be taken by those diagnosed with bipolar disorder.
Warnings
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
400 mg, 20 enteric coated tablets
Article no.: 557| # | Price | Discount Card |
|---|---|---|
| 1 | € 30,25 | € 27,23 |
| 3 | € 28,74 | € 25,87 |
