Glucosamine/Chondroitin Capsules
A naturally occurring amino sugar synthesized in the body from L-glutamine and glucose, glucosamine stimulates the manufacture of glycosaminoglycans, important components of the cartilage needed for healthy joints (37, 38). Aging people seem to lose their ability to produce a sufficient amount of glucosamine, and no food sources are available. Commercial sources of glucosamine from the exo-skeleton of certain shellfish are available as glucosamine sulfate, glucosamine hydrochloride, and N-acetyl-glucosamine. The sulfated form may most effectively incorporate sulfur into the cartilage (39, 40).
Glycosaminoglycans and glycoproteins allow cells in tissues to hold together. They are necessary for the construction and maintenance of virtually all connective tissues and lubricating fluids in the body (41,42). In particular, a combination of N-acetyl glucosamine bound to glucuronic acid, is polymerized to make the joint lubricant, hyaluronic acid.
Chondroitin sulfates provide the structural components of joint cartilage and facilitate the entry of glucosamine into joints. Chondroitin sulfates also inhibit free radical enzymes. Like glucosamine, chondroitin sulfate attracts water into the cartilage matrix and helps stimulate the production of cartilage.
Recent research suggests that chondroitin in combination with glucosamine sulfate has a positive effect on subchondral bone structural changes and may help augment repair processes following accessory joint tissue injury (43, 44). These important joint health agents may help maintain healthy joint structure and function, and reduce joint discomfort and stiffness (45-47).
References
37. Eksp Klin Farmakol. 2002 Nov-Dec;65(6):67-9.
38. Fortschr Med. 1980 Jun 5;98(21):801-6.
39. Osteoarthritis Cartilage. 2003 Jun;11(6):424-32.
40. Osteoarthritis Cartilage. 1998 Nov;6(6):427-34.
41. Perit Dial Int. 2007 Jun;27 Suppl 2:S104-9.
42. Perit Dial Int. 2007 Jul-Aug;27(4):375-90.
43. Arthritis Res Ther. 2007;9(6):R117.
44. Evid Based Complement Alternat Med. 2007 Jun;4(2):219-24.
45. Arthritis Rheum. 2007 Feb;56(2):555-67.
46. Rheumatol Int. 2007 Jan;27(3):213-8.
47. N Engl J Med. 2006 Feb 23;354(8):795-808.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 100
Amount Per Serving
Glucosamine sulfate (from 544 mg Glucosamine sulfate 2KCl) 400 mg
Chondroitin sulfate (from 500 mg Chondroitin sulfate sodium) 450 mg
Other ingredients: gelatin, vegetable stearate.
Contains crustacean shellfish (shrimp, crab).
This product contains NO milk, egg, fish, peanuts, soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule one to eight times daily with food, or as recommended by a healthcare practitioner.
Warnings
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Glycosaminoglycans and glycoproteins allow cells in tissues to hold together. They are necessary for the construction and maintenance of virtually all connective tissues and lubricating fluids in the body (41,42). In particular, a combination of N-acetyl glucosamine bound to glucuronic acid, is polymerized to make the joint lubricant, hyaluronic acid.
Chondroitin sulfates provide the structural components of joint cartilage and facilitate the entry of glucosamine into joints. Chondroitin sulfates also inhibit free radical enzymes. Like glucosamine, chondroitin sulfate attracts water into the cartilage matrix and helps stimulate the production of cartilage.
Recent research suggests that chondroitin in combination with glucosamine sulfate has a positive effect on subchondral bone structural changes and may help augment repair processes following accessory joint tissue injury (43, 44). These important joint health agents may help maintain healthy joint structure and function, and reduce joint discomfort and stiffness (45-47).
References
37. Eksp Klin Farmakol. 2002 Nov-Dec;65(6):67-9.
38. Fortschr Med. 1980 Jun 5;98(21):801-6.
39. Osteoarthritis Cartilage. 2003 Jun;11(6):424-32.
40. Osteoarthritis Cartilage. 1998 Nov;6(6):427-34.
41. Perit Dial Int. 2007 Jun;27 Suppl 2:S104-9.
42. Perit Dial Int. 2007 Jul-Aug;27(4):375-90.
43. Arthritis Res Ther. 2007;9(6):R117.
44. Evid Based Complement Alternat Med. 2007 Jun;4(2):219-24.
45. Arthritis Rheum. 2007 Feb;56(2):555-67.
46. Rheumatol Int. 2007 Jan;27(3):213-8.
47. N Engl J Med. 2006 Feb 23;354(8):795-808.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 100
Amount Per Serving
Glucosamine sulfate (from 544 mg Glucosamine sulfate 2KCl) 400 mg
Chondroitin sulfate (from 500 mg Chondroitin sulfate sodium) 450 mg
Other ingredients: gelatin, vegetable stearate.
Contains crustacean shellfish (shrimp, crab).
This product contains NO milk, egg, fish, peanuts, soybeans, tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule one to eight times daily with food, or as recommended by a healthcare practitioner.
Warnings
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
