HCA (Hydroxycitric acid)
HCA (hydroxycitric acid) is a close relative of citric acid, the agent that gives citrus fruits their characteristic tart flavor. HCA is obtained as a 50% standardized extract of Garcinia cambogia, a small fruit from southern India, where it has been used for centuries as a food preservative, flavoring agent, and digestive aid. HCA is a safe, natural supplement for weight management (92).
When calorie intake exceeds the body's energy needs, the excess glucose is converted into glycogen, which is stored in the liver and muscles for future conversion into energy. Weight gain occurs after the body's capacity for glycogen storage is reached. At this point, glucose from excessive calorie intake is converted into acetyl coenzyme A via a metabolic pathway involving the enzyme ATP-citrate lyase and then into fat molecules, which are stored in fat cells. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. HCA may reduce the synthesis of fatty acids in humans during a persistent excess of energy intake as carbohydrate (93).
It has been suggested that HCA promotes weight loss by increasing serotonin levels, reducing hunger and appetite, and suppressing carbohydrate conversion into fat by inhibiting ATP-citrate lyase (94-100), thus regulating fat and obesity related genes (101). HCA may also attenuate the increases in oxidative stress, and insulin resistance (102).
Supplement to be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
References
92. J Med. 2004;35(1-6):33-48.
93. Physiol Behav. 2006 Jul 30;88(4-5):371-81.
94. J Agric Food Chem. 2002 Jan 2;50(1):10-22.
95. Med Hypotheses. 1988 Sep;27(1):39-40.
96. Curr Concepts Nutr. 1983;12:139-67.
97. Acta Biochim Pol. 1976;23(2-3):227-34.
98. Lipids. 1974 Feb;9(2):121-8.
99. Lipids. 1974 Feb;9(2):129-34.
100. J Biol Chem. 1971 Feb 10;246(3):629-32.
101. DNA Cell Biol. 2007 Sep;26(9):627-39.
102. Mol Cell Biochem. 2007 Oct;304(1-2):93-9.
103. Food Chem Toxicol. 2004 Sep;42(9):1513-29.
104. Diabetes Obes Metab. 2004 May;6(3):171-80.
105. Diabetes Obes Metab. 1999 Nov;1(6):331-7.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 90
Amount Per Serving
Garcinia cambogia extract (vrucht) 500 mg
(standardized to 50% hydroxycitric acid (250 mg))
Other ingredients: gelatin.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, rice, sugar, artificial sweeteners, flavors, colors or preservatives.
Dosage and Use
Take one capsule three times daily, or as recommended by a healthcare practitioner. Best taken 45 minutes before meals.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
Citrimax is a registered trademark of InterHealth Nutraceuticals, Inc.
Caution:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
When calorie intake exceeds the body's energy needs, the excess glucose is converted into glycogen, which is stored in the liver and muscles for future conversion into energy. Weight gain occurs after the body's capacity for glycogen storage is reached. At this point, glucose from excessive calorie intake is converted into acetyl coenzyme A via a metabolic pathway involving the enzyme ATP-citrate lyase and then into fat molecules, which are stored in fat cells. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. HCA may reduce the synthesis of fatty acids in humans during a persistent excess of energy intake as carbohydrate (93).
It has been suggested that HCA promotes weight loss by increasing serotonin levels, reducing hunger and appetite, and suppressing carbohydrate conversion into fat by inhibiting ATP-citrate lyase (94-100), thus regulating fat and obesity related genes (101). HCA may also attenuate the increases in oxidative stress, and insulin resistance (102).
Supplement to be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
References
92. J Med. 2004;35(1-6):33-48.
93. Physiol Behav. 2006 Jul 30;88(4-5):371-81.
94. J Agric Food Chem. 2002 Jan 2;50(1):10-22.
95. Med Hypotheses. 1988 Sep;27(1):39-40.
96. Curr Concepts Nutr. 1983;12:139-67.
97. Acta Biochim Pol. 1976;23(2-3):227-34.
98. Lipids. 1974 Feb;9(2):121-8.
99. Lipids. 1974 Feb;9(2):129-34.
100. J Biol Chem. 1971 Feb 10;246(3):629-32.
101. DNA Cell Biol. 2007 Sep;26(9):627-39.
102. Mol Cell Biochem. 2007 Oct;304(1-2):93-9.
103. Food Chem Toxicol. 2004 Sep;42(9):1513-29.
104. Diabetes Obes Metab. 2004 May;6(3):171-80.
105. Diabetes Obes Metab. 1999 Nov;1(6):331-7.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 90
Amount Per Serving
Garcinia cambogia extract (vrucht) 500 mg
(standardized to 50% hydroxycitric acid (250 mg))
Other ingredients: gelatin.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, corn, rice, sugar, artificial sweeteners, flavors, colors or preservatives.
Dosage and Use
Take one capsule three times daily, or as recommended by a healthcare practitioner. Best taken 45 minutes before meals.
This supplement should be taken in conjunction with a healthy diet and regular exercise program. Results may vary.
Citrimax is a registered trademark of InterHealth Nutraceuticals, Inc.
Caution:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
