TMG
TMG is also called glycine betaine, but the name "trimethylglycine" signifies that it has three methyl groups attached to each molecule of glycine. Betaine was discovered to be beneficial to heart health back in the 1950s (90-94). TMG operates along a different pathway than the B vitamins. TMG acts as a "methyl donor," providing extra methyl groups to hasten the conversion of homocysteine back to methionine (95). When a TMG methyl group is donated to a molecule of homocysteine, it converts to the non-toxic amino acid, methionine, and then into S-adenosyl-methionine (SAMe) (96,97). Research showing TMG's ability to promote healthy levels of homocysteine, alone or in conjunction with other nutrients, confirms its status as an important nutrient for cardiovascular health (98-106). For example, in a recent cross-sectional survey study, participants who consumed >360 mg/d of betaine had, on average, 10% lower concentrations of homocysteine and 19% lower concentrations of C-reactive protein than did those who consumed <260 mg/d (107).
References
90. Ann West Med Surg. 1951;5:825-9.
91. Ann West Med Surg. 1951;5:830-55.
92. Ann West Med Surg. 1951;5:856-62.
93. JAMA. 1951;145:1232-6.
94. Am J Dig Dis. 1952;19:381-4.
95. Lawson-Yuen A et al. 2006
96. Biochemistry. 1999 Oct 19;38(42):13991-8.
97. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, DC.
98. J Nutr. 2003 Dec;133(12):4135-8.
99. J Nutr. 2003 May;133(5):1291-5.
100. Am J Clin Nutr. 2002 Nov;76(5):961-7.
101. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
102. Kidney Int. 2002 Mar;61(3):1040-6.
103. An Esp Pediatr. 1993 Jul;39(1):37-41.
104. Metabolism. 1985 Dec;34(12):1115-21.
105. N Engl J Med. 1983 Aug 25;309(8):448-53.
106. J Nutr. 2006 Jan;136(1):34-8.
107. Am J Clin Nutr 2008;87:424-30.
Supplement Facts
Serving Size 2 tablets
Servings Per Container 90
Amount Per Serving
Calcium (as dicalcium phosphate) 85 mg
Phosphorus (as dicalcium phosphate) 65 mg
Trimethylglycine (TMG) (as betaine anhydrous) 1000 mg
Other ingredients: microcrystalline cellulose, stearic acid, croscarmellose sodium, vegetable stearate, silicon dioxide, aqueous film coating (purified water, hydroxypropyl methylcellulose, natural wax, glycerin).
This product contains NO soybeans, milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take two tablets in the morning with or without food, or as recommended by a healthcare practitioner.
TMG should be taken with co-factors vitamins B6, B12, and folic acid.
Caution
If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
References
90. Ann West Med Surg. 1951;5:825-9.
91. Ann West Med Surg. 1951;5:830-55.
92. Ann West Med Surg. 1951;5:856-62.
93. JAMA. 1951;145:1232-6.
94. Am J Dig Dis. 1952;19:381-4.
95. Lawson-Yuen A et al. 2006
96. Biochemistry. 1999 Oct 19;38(42):13991-8.
97. Greene, R. C. 1996. Biosynthesis of methionine, p. 542-560. In F. C. Neidhardt, R. Curtiss III, J. L. Ingraham, E. C. C. Lin, K. B. Low, B. Magasanik, W. S. Reznikoff, M. Riley, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella: cellular and molecular biology, 2nd ed. ASM Press, Washington, DC.
98. J Nutr. 2003 Dec;133(12):4135-8.
99. J Nutr. 2003 May;133(5):1291-5.
100. Am J Clin Nutr. 2002 Nov;76(5):961-7.
101. Br J Clin Pharmacol. 2002 Aug;54(2):140-6.
102. Kidney Int. 2002 Mar;61(3):1040-6.
103. An Esp Pediatr. 1993 Jul;39(1):37-41.
104. Metabolism. 1985 Dec;34(12):1115-21.
105. N Engl J Med. 1983 Aug 25;309(8):448-53.
106. J Nutr. 2006 Jan;136(1):34-8.
107. Am J Clin Nutr 2008;87:424-30.
Supplement Facts
Serving Size 2 tablets
Servings Per Container 90
Amount Per Serving
Calcium (as dicalcium phosphate) 85 mg
Phosphorus (as dicalcium phosphate) 65 mg
Trimethylglycine (TMG) (as betaine anhydrous) 1000 mg
Other ingredients: microcrystalline cellulose, stearic acid, croscarmellose sodium, vegetable stearate, silicon dioxide, aqueous film coating (purified water, hydroxypropyl methylcellulose, natural wax, glycerin).
This product contains NO soybeans, milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), tree nuts, wheat, yeast, gluten, corn, or rice. Contains NO artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take two tablets in the morning with or without food, or as recommended by a healthcare practitioner.
TMG should be taken with co-factors vitamins B6, B12, and folic acid.
Caution
If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
