Ginkgo Biloba Certified Extract
For nearly 2800 years, the Chinese have used extracts from the Ginkgo biloba tree to treat a variety of conditions. Ginkgo helps promote healthy brain, metabolic, and cardiovascular function (i.e., blood, blood vessels, circulation) (150-170). Ginkgo contains numerous antioxidants such as proanthocyanidins and flavonoids that counteract free radical activity. Flavonoids are also known to strengthen capillaries, which can promote healthy blood flow to the brain to help maintain cognitive health (153,158,167).
Ginkgo may:
* Help maintain normal circulation by dilating blood vessels and reducing the stickiness of blood platelets (160,161)
* Help maintain the normal function and tone of blood vessels,153 and maintain a normal blood flow (150,152,159)
* Maintain already normal oxygen and glucose metabolism in the brain (154-157)
* Maintain normal coagulation of blood (161,162)
* Reduce tissue damage caused by low blood flow (154,161)
* Help control radiation-induced brain edemax in vitro (163-164)
* Help slow the aging process in the brain (159,165-168)
Ginkgo biloba extract is reputed as a neuroprotective antioxidant agent (169). It is known to protect the energy-producing mitochondria within the cells, thus enhancing oxygen utilization and cellular respiration.
In a study to determine whether ginkgo extract could prevent age-associated cellular changes, the brain and liver mitochondria of old mice fed ginkgo extract in their drinking water was compared to those of young and old control mice. Mitochondria from the rats given ginkgo exhibited significantly less genetic damage, peroxide generation, and oxidation of the crucial antioxidant glutathione than non-supplemented rats. In addition, mitochondria from old rats given the ginkgo extract resembled those of young rats much more closely, being similar in size and morphology. The study concluded that standardized ginkgo extract prevents age-related decline in mitochondrial structure and function by protecting mitochondria from oxidative damage (170).
The premium-quality botanical extract in Ginkgo Biloba Certified Extract™ has been concentrated and dual-standardized to ensure the highest quality, consistency, and biological activity.
The phytonutrient profile of Ginkgo Biloba Certified Extract™ is comparable to the GBE 24/6 extract used in clinical studies worldwide and monographed in German Commission E. The health regulatory agency that regulates ginkgo purity in Germany mandates that ginkgo not contain more than 5 ppm of ginkgolic acid. Ginkgo Biloba Certified Extract™ contains less than 1 ppm of ginkgolic acid. Ginkgolic acid is a substance related to anacardic acid (poison ivy) and may cause an allergic reaction in some people. Ginkgo Biloba Certified Extract™ has the lowest ginkgolic acid level commercially available.
Ginkgo Biloba Certified Extract™ has high levels of ginkgolide B (>0.8%), which is the most studied terpene lactone and thought to be a major regulator of platelet activating factor (PAF). PAF is a powerful physiologic- responses mediator for many processes (170).
References
150. Cell Mol Life Sci. 2003 Sep;60(9):1779-92.
151. Altern Med Rev. 2001 Apr;6(2):141-66.
152. Clin Physiol Funct Imaging. 2002 Nov;22(6):375-8.
153. Presse Med. 1986 Sep 25;15(31):1550-3.
154. Brain Res. 1997 May 2;755(2):347-50.
155. Clin Chim Acta. 2004 Feb;340(1-2):153-62.
156. Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S89-94.
157. Ann N Y Acad Sci. 2005 Nov;1056:474-85.
158. Rev Prat. 2000 Jun 1;50(11):1195-8.
159. Altern Ther Health Med. 2001 Sep-Oct;7(5):70-86, 88-90.
160. Int J Microcirc Clin Exp. 1997 Mar-Apr;17(2):61-6.
161. J Ethnopharmacol. 1996 Mar;50(3):131-9.
162. Pharmacol Res. 2002 Dec;46(6):565-8.
163. Phlebologie. 1991 Jul-Oct;44(3):779-86.
164. Phlebologie. 1991 Apr-Jun;44(2):509-16.
165. Acta Neurochir Suppl. 2000;76:87-90.
166. Presse Med. 1986 Sep 25;15(31):1575-6.
167. Pharmacopsychiatry. 1996 Mar;29(2):47-56.
168. Adv Ther. 1998 Jan-Feb;15(1):54-65.
169. Antioxid Redox Signal. 2007 Oct;9(10):1659-75.
170. Free Radic Biol Med. 1999; Sep;27(5-6):596-604.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 365
Amount Per Serving
Ginkgo biloba (leaf) extract [std. for 24% ginkgoflavonglycosides (28.8 mg), 6% total terpene lactones (7.2 mg), and <1ppm ginkgolic acid] 120 mg
Other ingredients: rice flour, gelatin, vegetable stearate.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule daily with or without food, or as recommended by a healthcare practitioner.
Caution:
If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your health care provider before taking this product.
Ginkgolic acid is an allergen for some people.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Ginkgo may:
* Help maintain normal circulation by dilating blood vessels and reducing the stickiness of blood platelets (160,161)
* Help maintain the normal function and tone of blood vessels,153 and maintain a normal blood flow (150,152,159)
* Maintain already normal oxygen and glucose metabolism in the brain (154-157)
* Maintain normal coagulation of blood (161,162)
* Reduce tissue damage caused by low blood flow (154,161)
* Help control radiation-induced brain edemax in vitro (163-164)
* Help slow the aging process in the brain (159,165-168)
Ginkgo biloba extract is reputed as a neuroprotective antioxidant agent (169). It is known to protect the energy-producing mitochondria within the cells, thus enhancing oxygen utilization and cellular respiration.
In a study to determine whether ginkgo extract could prevent age-associated cellular changes, the brain and liver mitochondria of old mice fed ginkgo extract in their drinking water was compared to those of young and old control mice. Mitochondria from the rats given ginkgo exhibited significantly less genetic damage, peroxide generation, and oxidation of the crucial antioxidant glutathione than non-supplemented rats. In addition, mitochondria from old rats given the ginkgo extract resembled those of young rats much more closely, being similar in size and morphology. The study concluded that standardized ginkgo extract prevents age-related decline in mitochondrial structure and function by protecting mitochondria from oxidative damage (170).
The premium-quality botanical extract in Ginkgo Biloba Certified Extract™ has been concentrated and dual-standardized to ensure the highest quality, consistency, and biological activity.
The phytonutrient profile of Ginkgo Biloba Certified Extract™ is comparable to the GBE 24/6 extract used in clinical studies worldwide and monographed in German Commission E. The health regulatory agency that regulates ginkgo purity in Germany mandates that ginkgo not contain more than 5 ppm of ginkgolic acid. Ginkgo Biloba Certified Extract™ contains less than 1 ppm of ginkgolic acid. Ginkgolic acid is a substance related to anacardic acid (poison ivy) and may cause an allergic reaction in some people. Ginkgo Biloba Certified Extract™ has the lowest ginkgolic acid level commercially available.
Ginkgo Biloba Certified Extract™ has high levels of ginkgolide B (>0.8%), which is the most studied terpene lactone and thought to be a major regulator of platelet activating factor (PAF). PAF is a powerful physiologic- responses mediator for many processes (170).
References
150. Cell Mol Life Sci. 2003 Sep;60(9):1779-92.
151. Altern Med Rev. 2001 Apr;6(2):141-66.
152. Clin Physiol Funct Imaging. 2002 Nov;22(6):375-8.
153. Presse Med. 1986 Sep 25;15(31):1550-3.
154. Brain Res. 1997 May 2;755(2):347-50.
155. Clin Chim Acta. 2004 Feb;340(1-2):153-62.
156. Pharmacopsychiatry. 2003 Jun;36 Suppl 1:S89-94.
157. Ann N Y Acad Sci. 2005 Nov;1056:474-85.
158. Rev Prat. 2000 Jun 1;50(11):1195-8.
159. Altern Ther Health Med. 2001 Sep-Oct;7(5):70-86, 88-90.
160. Int J Microcirc Clin Exp. 1997 Mar-Apr;17(2):61-6.
161. J Ethnopharmacol. 1996 Mar;50(3):131-9.
162. Pharmacol Res. 2002 Dec;46(6):565-8.
163. Phlebologie. 1991 Jul-Oct;44(3):779-86.
164. Phlebologie. 1991 Apr-Jun;44(2):509-16.
165. Acta Neurochir Suppl. 2000;76:87-90.
166. Presse Med. 1986 Sep 25;15(31):1575-6.
167. Pharmacopsychiatry. 1996 Mar;29(2):47-56.
168. Adv Ther. 1998 Jan-Feb;15(1):54-65.
169. Antioxid Redox Signal. 2007 Oct;9(10):1659-75.
170. Free Radic Biol Med. 1999; Sep;27(5-6):596-604.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 365
Amount Per Serving
Ginkgo biloba (leaf) extract [std. for 24% ginkgoflavonglycosides (28.8 mg), 6% total terpene lactones (7.2 mg), and <1ppm ginkgolic acid] 120 mg
Other ingredients: rice flour, gelatin, vegetable stearate.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, and no artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule daily with or without food, or as recommended by a healthcare practitioner.
Caution:
If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your health care provider before taking this product.
Ginkgolic acid is an allergen for some people.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
