Acetyl-L-Carnitine Arginate
A major cause of aging is deterioration of the energy-producing components of the cell, resulting in reduced cellular metabolic activity, the accumulation of cellular debris and eventually cell death (1-7). L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria within the cell, where fats are oxidized to produce the cellular energy ATP (8-13).
Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging (14). Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently. Both are effective at carrying fatty acids across the membrane into the cell where they are burned as energy and utilized efficiently by the mitochondria (15-17). Acetyl-L-carnitine also guards against oxidative damage (18,19). Amyloid-beta peptide is a principal component of senile plaques and is thought to be central to the pathogenesis of the degenerating process. Acetyl-L-carnitine exerts protective effects against A-beta neurotoxicity and oxidative stress (14).
Acetyl-L-carnitine arginate is a patented form of carnitine. Studies show that it stimulates the growth of neurites in the brain by 19.5%, which is almost four times better than acetyl-L-carnitine (21).
The acetylated form of L-carnitine (acetyl-L-carnitine) facilitates the release and synthesis of acetylcholine by donating its acetyl group to the production of acetylcholine, an important neurotransmitter (25). Acetyl-L-carnitine also enhances the release of dopamine from neurons and helps it bind to dopamine receptors (26, 27).
With the discovery of acetyl-L-carnitine arginate, the benefits of acetyl-L-carnitine can now be greatly augmented.
References
1. Physiol Rev.1998 Apr;78(2):547-81. http://physrev.physiology.org/cgi/content/full/78/2/547
2. Ann N Y Acad Sci. 2004 Jun;1019:406-11.
3. Age. 1983 6:86-94.
4. Exp Gerontol. 1984;19(1):31-6.
5. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771-8.
6. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3064-9.
7. Ann N Y Acad Sci. 1998 Nov 20;854:118-27.
8. Brain Res. 1990 Aug 27;526(1):108-12.
9. Metabolism. 1997 Dec;46(12):1454-7.
10. Mech Ageing Dev. 1995 Oct 13;84(2):103-12.
11. Ann N Y Acad Sci. 2002 Apr;959:491-507.
12. Physiol Rev. 1983 Oct;63(4):1420-80.
13. Am J Clin Nutr. 2007 Dec;86(6):1738-44.
14. J Neurosci Res. 2006 Aug 1;84(2):398-408.
15. Acta Diabetol. 2003 Oct;40 Suppl 1:S106-13.
16. Biochim Biophys Acta. 2000 Jun 26;1486(1):1-17.
17. J Clin Invest. 1989 Oct;84(4):1167-73.
18. Exp Physiol. 2008 Oct;93(10):1139-46. Epub 2008 Jun 20.
19. Neurochem Res. 2008 Oct 10. [Epub ahead of print]
21. Neurochem Res.1995 Jan;20(1):1-9.
25. J Neurosci Res. 2001 Oct 15;66(2):266-71.
26. J Neurosci Res. 1991 Nov;30(3):555-9.
27. Eur J Pharmacol. 1992 Jul 21;218(1):117-21.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 100
Amount Per Serving
Acetyl-L-Carnitine Hydrochloride 300 mg
Acetyl-L-Carnitine Arginate Dihydrochloride 320 mg
Other ingredients: rice flour, gelatin, stearic acid, silicon dioxide, vegetable stearate.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule three times daily, preferably on an empty stomach, or as recommended by a healthcare practitioner.
This product can be taken in divided doses or all at once.
Caution
For some people, L-carnitine, especially acetyl-L-carnitine, may have a stimulating effect. Therefore, it may be unwise to take it in the evening.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Acetyl-L-carnitine is the acetylated ester of the amino acid L-carnitine. Acetyl-L-carnitine is an endogenous mitochondrial membrane compound that helps maintain mitochondrial bioenergetics and lowers the increased oxidative stress associated with aging (14). Acetyl-L-carnitine and L-carnitine are absorbed into the bloodstream efficiently. Both are effective at carrying fatty acids across the membrane into the cell where they are burned as energy and utilized efficiently by the mitochondria (15-17). Acetyl-L-carnitine also guards against oxidative damage (18,19). Amyloid-beta peptide is a principal component of senile plaques and is thought to be central to the pathogenesis of the degenerating process. Acetyl-L-carnitine exerts protective effects against A-beta neurotoxicity and oxidative stress (14).
Acetyl-L-carnitine arginate is a patented form of carnitine. Studies show that it stimulates the growth of neurites in the brain by 19.5%, which is almost four times better than acetyl-L-carnitine (21).
The acetylated form of L-carnitine (acetyl-L-carnitine) facilitates the release and synthesis of acetylcholine by donating its acetyl group to the production of acetylcholine, an important neurotransmitter (25). Acetyl-L-carnitine also enhances the release of dopamine from neurons and helps it bind to dopamine receptors (26, 27).
With the discovery of acetyl-L-carnitine arginate, the benefits of acetyl-L-carnitine can now be greatly augmented.
References
1. Physiol Rev.1998 Apr;78(2):547-81. http://physrev.physiology.org/cgi/content/full/78/2/547
2. Ann N Y Acad Sci. 2004 Jun;1019:406-11.
3. Age. 1983 6:86-94.
4. Exp Gerontol. 1984;19(1):31-6.
5. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10771-8.
6. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3064-9.
7. Ann N Y Acad Sci. 1998 Nov 20;854:118-27.
8. Brain Res. 1990 Aug 27;526(1):108-12.
9. Metabolism. 1997 Dec;46(12):1454-7.
10. Mech Ageing Dev. 1995 Oct 13;84(2):103-12.
11. Ann N Y Acad Sci. 2002 Apr;959:491-507.
12. Physiol Rev. 1983 Oct;63(4):1420-80.
13. Am J Clin Nutr. 2007 Dec;86(6):1738-44.
14. J Neurosci Res. 2006 Aug 1;84(2):398-408.
15. Acta Diabetol. 2003 Oct;40 Suppl 1:S106-13.
16. Biochim Biophys Acta. 2000 Jun 26;1486(1):1-17.
17. J Clin Invest. 1989 Oct;84(4):1167-73.
18. Exp Physiol. 2008 Oct;93(10):1139-46. Epub 2008 Jun 20.
19. Neurochem Res. 2008 Oct 10. [Epub ahead of print]
21. Neurochem Res.1995 Jan;20(1):1-9.
25. J Neurosci Res. 2001 Oct 15;66(2):266-71.
26. J Neurosci Res. 1991 Nov;30(3):555-9.
27. Eur J Pharmacol. 1992 Jul 21;218(1):117-21.
Supplement Facts
Serving Size 1 capsule
Servings Per Container 100
Amount Per Serving
Acetyl-L-Carnitine Hydrochloride 300 mg
Acetyl-L-Carnitine Arginate Dihydrochloride 320 mg
Other ingredients: rice flour, gelatin, stearic acid, silicon dioxide, vegetable stearate.
Contains rice.
This product contains NO milk, egg, fish, peanuts, crustacean shellfish (lobster, crab, shrimp), soybeans, tree nuts, wheat, yeast, gluten, or corn. Contains NO sugar, artificial sweeteners, flavors, colors, or preservatives.
Dosage and Use
Take one capsule three times daily, preferably on an empty stomach, or as recommended by a healthcare practitioner.
This product can be taken in divided doses or all at once.
Caution
For some people, L-carnitine, especially acetyl-L-carnitine, may have a stimulating effect. Therefore, it may be unwise to take it in the evening.
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
