Boswella
As people age, systemic inflammation can inflict degenerative effects throughout the body (1-5) A primary cause of this destructive cascade is the production of cell-signaling chemicals known as inflammatory cytokines. Along with these dangerous cytokines, imbalances of hormone-like messengers called prostaglandins also contribute to inflammatory processes.
Boswella is composed of boswellic acids, an extract of the resin of the Boswellia serrata tree which grows in India. Boswellic acids are effective at blocking the synthesis of pro-inflammatory 5-lipoxygenase products, including 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. Boswellic acids may also mediate their inflammatory actions by inhibiting cyclooxygenases, preferentially COX-1 (59-67).
In addition, the combination of boswellic acids and glucosamine may have a synergistic favorable effect on inflammatory conditions (68).
References
1. Eur J Clin Invest. 2004 May;34(5):335-41.
2. JAMA. 2004 Feb 11;291(6):704-10.
3. Ann Rheum Dis. 2004 Feb;63(2):200-5.
4. Biol Psychiatry. 2003 Sep 1;54(5):566-72.
5. Immunol Allergy Clin North Am. 2003 Feb;23(1):15-39.
59. Wien Med Wochenschr. 2002;152(15-16):373-8.
60. Planta Med. 2001 Jul;67(5):391-5.
61. Planta Med. 2000 Mar;66(2):110-3.
62. Eur J Med Res. 1998 Nov 17;3(11):511-4.
63. Eur J Med Res. 1997 Jan;2(1):37-43.
64. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
65. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
66. Planta Med. 1991 Jun;57(3):203-7.
67. Biochem Pharmacol. 2007 Sep 14 [Epub ahead of print]
68. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3706-11.
Supplement Facts
Serving Size 1 softgel
Servings Per Container 100
Amount Per Serving
Boswellia 500 mg
(stand. 300 mg Boswella acids)
Dosage and Use
Take one capsule three times daily with food, or as recommended by a healthcare practitioner.
Caution:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Boswella is composed of boswellic acids, an extract of the resin of the Boswellia serrata tree which grows in India. Boswellic acids are effective at blocking the synthesis of pro-inflammatory 5-lipoxygenase products, including 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4), which cause bronchoconstriction, chemotaxis, and increased vascular permeability. Boswellic acids may also mediate their inflammatory actions by inhibiting cyclooxygenases, preferentially COX-1 (59-67).
In addition, the combination of boswellic acids and glucosamine may have a synergistic favorable effect on inflammatory conditions (68).
References
1. Eur J Clin Invest. 2004 May;34(5):335-41.
2. JAMA. 2004 Feb 11;291(6):704-10.
3. Ann Rheum Dis. 2004 Feb;63(2):200-5.
4. Biol Psychiatry. 2003 Sep 1;54(5):566-72.
5. Immunol Allergy Clin North Am. 2003 Feb;23(1):15-39.
59. Wien Med Wochenschr. 2002;152(15-16):373-8.
60. Planta Med. 2001 Jul;67(5):391-5.
61. Planta Med. 2000 Mar;66(2):110-3.
62. Eur J Med Res. 1998 Nov 17;3(11):511-4.
63. Eur J Med Res. 1997 Jan;2(1):37-43.
64. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
65. J Pharmacol Exp Ther. 1992 Jun;261(3):1143-6.
66. Planta Med. 1991 Jun;57(3):203-7.
67. Biochem Pharmacol. 2007 Sep 14 [Epub ahead of print]
68. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3706-11.
Supplement Facts
Serving Size 1 softgel
Servings Per Container 100
Amount Per Serving
Boswellia 500 mg
(stand. 300 mg Boswella acids)
Dosage and Use
Take one capsule three times daily with food, or as recommended by a healthcare practitioner.
Caution:
Keep out of reach of children.
Do not exceed recommended dose.
Do not purchase if outer seal is broken or damaged.
If you have a bad reaction to product discontinue use immediately.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
